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Subscribe to Optimal on these popular channels Optimal - The Podcast: Episode 6 - Inflammation with a Focus on Cytokines Dr. Dicken Weatherby & Beth Ellen DiLuglio, MS, RDN, LDN Welcome to episode 6 of "Optimal - The Podcast". In this episode of Optimal, we are going to talk about inflammation, with a focus on the role of cytokines.

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Inflammation: Resolution and Intervention Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN Remember that inflammation serves a purpose, including killing off pathogens and clearing away damaged tissue and debris. However, resolution of inflammation is the key to healing and recovery.

Ratio of IL-6 to IL-10 Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN Research suggests that evaluating the ratio of IL-6 to IL-10 may be more clinically useful than measuring either cytokine alone.

Interleukin-10 (IL-10) Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN Interleukin-10 is an anti-inflammatory cytokine that curbs IL-6, TNF-alpha, and IL-8 pro-inflammatory activity. [1]

Interleukin-6 (IL-6) Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN Interleukin-6 is one of a number of compounds in the IL-6 family which includes IL-11, IL-27, IL-31, and other metabolically active compounds. [1]

Establishing “normal” ranges for serum cytokines... an elusive endeavor Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN As research progresses, guidelines for cytokine evaluation are emerging though “normal versus abnormal” ranges are difficult to determine with certainty due to the dynamic nature of the cytokine response.

Cytokine Biomarkers Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN Inflammatory cytokines, as well as inflammatory proteins (e.g., CRP, SAA), and abnormal activation of certain enzymes (e.g., COX-2, SOD, glutathione peroxidase/GPx, iNOS), may serve as biomarkers of disease presence and progression in inflammatory disorders such as infection, cardiovascular disease, and endothelial disfunction. [1]

Unbridled inflammation and the cytokine storm Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN Resolution of inflammation is just as important as its initiation. Early inflammation can help fight pathogens and clear damaged tissue. However, prolonged inflammation can cause cellular damage leading to organ compromise.

Sources of Cytokines and their Function Dicken Weatherby, N.D. and Beth Ellen DiLuglio, MS, RDN, LDN A wide variety of cells produce cytokines, including fibroblasts, nerve, mast, glial, adipose, and endothelial cells, though macrophages and helper T (Th) lymphocytes are the primary producers.[1]